2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1403R
    Dienestrol (Standard) 84-17-3
    Dienestrol (Standard) is the analytical standard of Dienestrol (HY-B1403). This product is intended for research and analytical applications. Dienestrol is an orally active nonsteroidal estrogen. Dienestrol prevents the formation of implantation swellings in the uterus by inhibiting ovum discharge.
    Dienestrol (Standard)
  • HY-B1435R
    Moxisylyte hydrochloride (Standard) 964-52-3 98%
    Moxisylyte (Thymoxamine) hydrochloride Standard is the analytical standard of Moxisylyte hydrochloride (HY-B1435). This product is intended for research and analytical applications. Moxisylyte (Thymoxamine) hydrochloride is a selective α1A-adrenergic receptor antagonist. Moxisylyte hydrochloride competitively antagonizes the activation mediated by norepinephrine. Moxisylyte hydrochloride relaxes penile cavernous smooth muscle and aids erectile function. Moxisylyte hydrochloride is applicable to research related to erectile dysfunction and multiple system atrophy.
    Moxisylyte hydrochloride (Standard)
  • HY-B1451R
    Imidapril hydrochloride (Standard) 89396-94-1 98%
    Imidapril (hydrochloride) (Standard) is the analytical standard of Imidapril (hydrochloride). This product is intended for research and analytical applications. Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.
    Imidapril hydrochloride (Standard)
  • HY-B1469R
    Isosorbide (Standard) 652-67-5 98%
    Isosorbide (Standard) is the analytical standard of Isosorbide. This product is intended for research and analytical applications. Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic.
    Isosorbide (Standard)
  • HY-B1476R
    NSC 42196 (Standard) 17140-60-2 98%
    NSC 42196 (Standard) is the analytical standard of NSC 42196. This product is intended for research and analytical applications. NSC 42196 is an endogenous metabolite.
    NSC 42196 (Standard)
  • HY-B1477R
    Clopamide (Standard) 636-54-4
    Clopamide (Standard) is the analytical standard of Clopamide. This product is intended for research and analytical applications. Clopamide is an orally active thiazide-like diuretic agent that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide has the potential for hypertension and cardiac failure research.
    Clopamide (Standard)
  • HY-B1557R
    Betazole (Standard) 105-20-4
    Betazole (Standard) is the analytical standard of Betazole. This product is intended for research and analytical applications. Betazole (Ametazole), a pyrazole analogue of histamine, is an orally active histamine H2 receptor agonist. Betazole induces gastric acid secretion and causes an immediate and significant increase in common bile duct pressure. Betazole is used as a diagnostic agent known as histalog for investigating gastric acid secretory capacity.
    Betazole (Standard)
  • HY-B1667R
    Isopropamide iodide (Standard) 71-81-8
    Isopropamide (iodide) (Standard) is the analytical standard of Isopropamide (iodide). This product is intended for research and analytical applications. Isopropamide iodide is a long-acting quaternary anticholinergic agent. Isopropamide iodide is used in peptic ulcer and other gastrointestinal disorders marked by hyperacidity and hypermotility.
    Isopropamide iodide (Standard)
  • HY-B1671R
    (+)-Kavain (Standard) 500-64-1
    (+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
    (+)-Kavain (Standard)
  • HY-B1724R
    Perflubron (Standard) 423-55-2 98%
    Perflubron (Standard) is the analytical standard of Perflubron. This product is intended for research and analytical applications. Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics.
    Perflubron (Standard)
  • HY-B1858R
    Isoprothiolane (Standard) 50512-35-1 98%
    Isoprothiolane (Standard) is the analytical standard of Isoprothiolane (HY-B1858). This product is intended for research and analytical applications. Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane (Standard)
  • HY-B1858S
    Isoprothiolane-d4 1715020-82-8 98%
    Isoprothiolane-d4 is the deuterium labeled Isoprothiolane (HY-B1858). Isoprothiolane is a blast fungicide with antifungal, anti-inflammatory and insecticidal activities. Isoprothiolane primarily acts on fungi during the penetration and growth stages of infecting hyphae. Isoprothiolane can be used as an insecticide, pesticide, etc. In addition, Isoprothiolane can reduce serum phospholipid and total lipid concentrations, regulating lipid metabolism. Isoprothiolane is also used in the research of fatty liver.
    Isoprothiolane-d4
  • HY-B1966S
    Diphenyl phthalate-3,4,5,6-d4 1398065-61-6 98%
    Diphenyl phthalate-3,4,5,6-d4 is the deuterium labeled Diphenyl phthalate.
    Diphenyl phthalate-3,4,5,6-d4
  • HY-B1986R
    p,p'-DDE (Standard) 72-55-9 98%
    p,p'-DDE (Standard) is the analytical standard of p,p'-DDE. This product is intended for research and analytical applications. p,p'-DDE (4,4'-DDE) is the major and persistent metabolite of DDT. p,p'-DDE is a orally active androgen receptor antagonist with an IC50 of 5 μM and a Ki of 3.5 μM. p,p'-DDE can affect the development and function of the male reproductive system. Additionally, high serum concentrations of p,p'-DDE may be a risk factor for type 2 diabetes in women.
    p,p'-DDE (Standard)
  • HY-B2007R
    Fluazifop-P-butyl (Standard) 79241-46-6
    Fluazifop-P-butyl (Standard) is the analytical standard of Fluazifop-P-butyl (HY-B2007). This product is intended for research and analytical applications. Fluazifop-P-butyl is an orally active herbicide and ACCase inhibitor. Fluazifop-P-butyl blocks the formation of malonyl-CoA, disrupts lipid synthesis in sensitive plants, and exhibits concentration-dependent phytotoxicity to non-target maize seedlings. Fluazifop-P-butyl induces oxidative stress in male Wistar rats, impairs their liver and kidney functions, and disrupts testicular function.
    Fluazifop-P-butyl (Standard)
  • HY-B2010R
    Fomesafen (Standard) 72178-02-0
    Fomesafen (Standard) is the analytical standard of Fomesafen (HY-B2010). This product is intended for research and analytical applications. Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards.
    Fomesafen (Standard)
  • HY-B2089R
    Cinitapride (Standard) 66564-14-5
    Cinitapride (Standard) is the analytical standard of Cinitapride. This product is intended for research and analytical applications. Cinitapride is a nonselective 5-HT1 and 5-HT4 receptors agonist and a 5-HT2 and D2 antagonist. Cinitapride can be used in functional dyspepsia (FD) and gastroesophageal reflux disease (GERD) research.
    Cinitapride (Standard)
  • HY-B2155R
    Acotiamide monohydrochloride trihydrate (Standard) 773092-05-0 98%
    Acotiamide (monohydrochloride trihydrate) (Standard) is the analytical standard of Acotiamide (monohydrochloride trihydrate). This product is intended for research and analytical applications. Acotiamide monohydrochloride trihydrate is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with IC50 of 1.79 μM. Acotiamide monohydrochloride trihydrate can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide monohydrochloride trihydrate has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory .
    Acotiamide monohydrochloride trihydrate (Standard)
  • HY-B2188R
    S-Methyl-L-cysteine (Standard) 1187-84-4
    S-Methyl-L-cysteine (Standard) is the analytical standard of S-Methyl-L-cysteine. This product is intended for research and analytical applications. S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.
    S-Methyl-L-cysteine (Standard)
  • HY-B2223R
    Thiamine nitrate (Standard) 532-43-4 98%
    Thiamine nitrate (Standard) is the analytical standard of Thiamine nitrate. This product is intended for research and analytical applications. Thiamine nitrate is an essential vitamin which can enhance normal neuronal actives.
    Thiamine nitrate (Standard)
Cat. No. Product Name / Synonyms Application Reactivity